Generic Memantine – Altizin 10mg
Generic memantine is presented is an Indian drug with the brand name ALZITIN-5, ALZITIN-10, a quality remedy for the treatment of dementia. Analogue Akatinol Memantine, but better and cheaper, because the newer. Suitable drug on request memantine analogues, before use, carefully read the instructions, read the doctor’s appointment.
Pharmacokinetics of the drug
After ingestion is quickly and completely absorbed. Cmax in the blood plasma is reached within 2–6 hours. In normal renal function, cumulation of the drug is not observed. Withdrawal proceeds in two phases. T1 / 2 is in the first phase – 4–9 hours, in the second – 40–65 hours. Excreted in the urine.
Pharmacodynamics of the drug
Being a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, it has a modulating effect on the glutamatergic system. It regulates ion transport, blocks calcium channels, normalizes membrane potential, improves the transmission of nerve impulses. Improves cognitive processes, increases daily activity.
Indications for use
Alzheimer’s type dementia, vascular dementia, mixed dementia of all degrees of severity.
Contraindications indicated by the manufacturer
Individual hypersensitivity to the drug;
severe renal impairment;
children’s age up to 18 years (due to lack of data).
convulsions (including in history);
Use during pregnancy and lactation
Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.
Side effects when applying
Adverse reactions are classified by clinical manifestations (according to the lesion of certain organ systems) and by frequency of occurrence: very often часто 1/10; often – 1 / 100– <1/10; infrequently -? 1 / 1000–? 1/100); rarely – 1 / 10,000– <1/1000; very rarely – 1/10000; Frequency is not established – currently there are no data on the prevalence of adverse reactions.
1. On the part of the body as a whole – common adverse reactions: Often – Headache; Rarely-Fatigue
2. Infections: Rarely – Fungal infections
3. Mental disorders: Often – Drowsiness; Rarely – Confusion and Hallucinations *; Frequency not established – Psychotic reactions **
4. Disorders of the cardiovascular system: Rarely – Hypertension; Rarely – Venous thrombosis / thromboembolism
5. Gastrointestinal disorders: Often – Constipation; Rarely – Nausea, vomiting; Frequency is not installed – Pancreatitis2
6. Disturbances of the central and peripheral nervous system: Often – Dizziness; Rarely – gait disturbance; Very rarely – Convulsions
* Hallucinations have been observed mainly in Alzheimer’s patients with severe dementia.
** There are separate reports of the occurrence of these adverse reactions when using the drug in clinical practice (data obtained after the appearance of the drug on the market).
Interaction with drugs
With simultaneous use with drugs L-dopa, dopamine agonists, anticholinergic agents, the action of the latter can be enhanced. With simultaneous use with barbiturates, neuroleptics, the effect of the latter may be reduced. When used together, it can change (increase or decrease) the effect of dantrolene or baclofen, so the doses of drugs should be selected individually. Concurrent administration with amantadine, ketamine and dexamethorphan should be avoided. There may be an increase in plasma levels of cimetidine, procainamide, quinidine, kinin and nicotine while taking it with memantine. May decrease the level of hydrochlorothiazide while taking with memantine.
Overdose when taking
Symptoms: increased severity of side effects.
Treatment: gastric lavage, taking activated charcoal, symptomatic therapy.
Dosage and administration
Inside, while eating. The dosing regimen is set individually. It is recommended to begin treatment with the appointment of the minimum effective doses.
Adults with dementia during the 1st week of therapy – at a dose of 5 mg / day, 2nd week – at a dose of 10 mg / day, 3rd week – at a dose of 15-20 mg / day. If necessary, a further weekly dose increase of 10 mg is possible until a daily dose of 30 mg is reached.
The optimal dose is achieved gradually, with an increase in dose every week.
Special instructions for use
Be wary appointed with epilepsy, patients with thyrotoxicosis. The optimal dose is achieved gradually, with a weekly increase.
Special instructions for use
Patients with Alzheimer’s disease at the stage of moderate and severe dementia usually have impaired ability to drive vehicles and control complex mechanisms. In addition, memantine may cause a change in the reaction rate, therefore, patients receiving outpatient treatment should take special care when driving vehicles or driving mechanisms.